K4DD continues to produce impact  

While the K4DD project has officially ended, the impact of the project still continues to resonate.Read more


Multidisciplinary K4DD paper suggests new strategy for drug discovery  

A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in “Nature Communications”, suggest a new strategy for drug discovery. The research was done in the framework of the Kinetics for Drug Discovery K4DD consortium. Read more


‘Binding Kinetics: Time is of the essence’ – a successful and inspiring meeting  

In its final month the K4DD consortium gathered for one last time to discuss the importance of drug target binding kinetics in drug discovery. For this final meeting the K4DD consortium opened its doors and invited the scientific community to participate in an open scientific meeting. Read more


K4DD research published in Structure  

Work from K4DD partner Heptares has resulted in a publication in the high-impact journal Structure. The comprehensive study describes the structure of the Adenosine A1 and A2A receptors with xanthine-based ligands. The Adenonsine receptors are expressed in many cell types and have been suggested to be good therapeutic targets in treating a wide variety of CNS, cardiovascular, respiratory, and...Read more


K4DD publishes a comprehensive overview article on Drug-Target binding kinetics  

In a true Public-Private effort, 9 K4DD partners have joined their knowledge and experience to establish a comprehensive overview article of drug Target-Binding Kinetics. The article published in Drug Discovery today can now freely be accessed using the following link.Read more


K4DD project results in first PhD thesis  

Binding interactions between neuropeptides (body’s neural signalling molecules), drugs and their target molecules were the focus of the first PhD thesis defense resulting from IMI’s K4DD project. Idira Nederpelt of Leiden University was the author of the thesis which already resulted in six peer-reviewed publications, with more to come. The thesis has helped expand the toolbox of...Read more


K4DD Scientific Meeting: "Binding kinetics: Time is of the essence"  

On 16-18 October, K4DD will organize an open scientific meeting. The meeting will be hosted by K4DD coordinator Bayer in Berlin, Germany.Read more