K4DD Scientific Meeting: "Binding kinetics: Time is of the essence"  

On 16-18 October, K4DD will organize an open scientific meeting. The meeting will be hosted by K4DD coordinator Bayer in Berlin, Germany.Read more


K4DD enters 2017 with the acceptance of another public private publication  

K4DD got off to a good start in 2017: we are happy to report the acceptance of another joint public-private research article (Hothersall et al., 2017). Looking back, 2016 was the most successful year so far for the project, with in total 16 K4DD publications. The project maintains it momentum in the new year and is determined to make 2017 - the final year of K4DD - an even bigger success. In...Read more


K4DD pharmacologists find new ways to predict the duration of drug effects  

The selection of new drug candidates can be improved by modeling drug-specific and disease-specific properties. This is the result of research done within the Kinetics of Drug Discovery (K4DD) project and has been published in Elseviers' Trends in Pharmacological Sciences. K4DD researchers from the Leiden University have presented a mathematical approximation to understand and visualize the...Read more


K4DD member organizes EFMC course  

K4DD members Ad IJzerman and Laura Heitman will be hosting an EFMC short course centered on drug-target binding kinetics. The, A matter of time: A kinetic perspective on drug-target interactions course will be organized in Leiden, The Netherlands on April 23-26, 2017. In this EFMC short course experts in the field will provide a firm conceptual framework for the study of target binding kinetics....Read more


K4DD publication highlights the case for partnership  

With a recent publication in the Journal of Medicinal Chemistry, the Kinetics for Drug Discovery consortium highlights the value of collaboration between public and private partners. Heptares and the Univeristy of Leiden, both K4DD partners, joined forces to investigate drug target binding kinetics of the human A2A adenosine receptor. The results of the public private partnership shed light on...Read more


Three K4DD partners have been granted 33 million CPU hours in PRACE call.  

K4DD partners Sanofi, HITS and University of Bochum have submitted a project to the 12th Project Access call of the PRACE research infrastructure. The goal of their multi-year project is to compare several methods based on biased Molecular Dynamics for the prediction of binding kinetics constants using high quality datasets generated within the K4DD consortium. Their submission entitled...Read more


K4DD publication recommended in Faculty of 1000  

The K4DD article: "The Role of Target Binding Kinetics in Drug Discovery" by Dong Guo, Laura Heitman and Ad IJzerman in the Journal Chemmedchem, (DOI: 10.1002/cmdc.201500310), has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Peter R Bernstein. You can read Dr Bernstein's recommendation here. Have a look at our publication section...Read more