A joint industry/academia study of a cancer target protein reveals unusual relation between binding site flexibility and drug-target lifetime. The results, published in “Nature Communications”, suggest a new strategy for drug discovery. The research was done in the framework of the Kinetics for Drug Discovery K4DD consortium.
In its final month the K4DD consortium gathered for one last time to discuss the importance of drug target binding kinetics in drug discovery. For this final meeting the K4DD consortium opened its doors and invited the scientific community to participate in an open scientific meeting.
Work from K4DD partner Heptares has resulted in a publication in the high-impact journal Structure. The comprehensive study describes the structure of the Adenosine A1 and A2A receptors with xanthine-based ligands. The Adenonsine receptors are expressed in many cell types and have been suggested to be good therapeutic targets in treating a wide variety of CNS, cardiovascular, respiratory, and...
In a true Public-Private effort, 9 K4DD partners have joined their knowledge and experience to establish a comprehensive overview article of drug Target-Binding Kinetics. The article published in Drug Discovery today can now freely be accessed using the following link.
Binding interactions between neuropeptides (body’s neural signalling molecules), drugs and their target molecules were the focus of the first PhD thesis defense resulting from IMI’s K4DD project. Idira Nederpelt of Leiden University was the author of the thesis which already resulted in six peer-reviewed publications, with more to come. The thesis has helped expand the toolbox of...
On 16-18 October, K4DD will organize an open scientific meeting. The meeting will be hosted by K4DD coordinator Bayer in Berlin, Germany.
K4DD got off to a good start in 2017: we are happy to report the acceptance of another joint public-private research article (Hothersall et al., 2017). Looking back, 2016 was the most successful year so far for the project, with in total 16 K4DD publications. The project maintains it momentum in the new year and is determined to make 2017 - the final year of K4DD - an even bigger success. In...